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GLP-1RAs can downregulate the expression of the myostatin gene in C2C12 myotubes, reversing the upregulation of atrophy factors and downregulation of myogenic factors (MyoD/G) (136)

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Also, GLP-1 delays gastric emptying ( 5 ), increases satiety, suppresses food intake, and reduces weight in humans ( 6, 7 )